Centers & Clinics

Pioneering Rehabilitation

Mission Statement

In the U.S. alone, more than 100 million people suffer from chronic pain.* Chronic pain is frequently resistant to treatment with either anti-inflammatory drugs or opiates.

Scientists at the Burke Medical Research Institute are actively involved in pain research, pursuing new concepts to better understand how chronic pain establishes itself after trauma or disease, and to develop novel therapeutic approaches to improve the lives of pain patients. We have established the Center for Pain and Sensory Recovery at Burke Medical Research Institute to focus, grow and optimally deploy our expertise in both basic and clinical pain research.

Burke Medical Research Institute is an academic affiliate of the Weill Medical College of Cornell University.

* Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education and Research. The National Academies Press, 2011.

Upcoming Seminars

Date: Tuesday, January 19, 2016
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Wenqin Luo, MD, Ph.D., Assistant Professor, Department of Neuroscience Perelman School of Medicine, University of Pennsylvania
Seminar Title:“Development, Organization, and Function of Mammalian Touch and Pain Sensory Neurons"

Date: Tuesday, January 26, 2015
Time: 9:30 AM
Location: Kelsey Library
Journal Club, Burke Center for Pain and Sensory Recovery
Presenter: Dianna Willis, Ph.D. (Willis lab)
Paper: "The RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy." Experimental Neurology 261 (2014) 343-353.

Past Seminars

Date: Tuesday, December 1, 2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Ru-Rong Ji. Ph.D., Distinguished Professor, Chief of Pain Research, Departments of Anesthesiology and Neurobiology
Seminar Title:"Chronic Pain Control by Neuroinflammation and Stem Cells" Duke University Medical Center

Date: Tuesday, November 10, 2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Alban Latremoliere, Ph.D., F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School
Seminar Title: "Sepiapterin Reductase as a Novel Target to Treat Neuropathic Pain

Date: Tuesday, September 22, 2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Stephen G. Waxman, M.D., Ph.D., Bridget M. Flaherty Professor of Neurology, Neurobiology, and Pharmacology; Director, Center for Neuroscience and Regeneration Research, Yale School of Medicine and VA Connecticut
Seminar Title: “Chasing men on fire: Sodium Channels and Pain”

Date: Tuesday, July 7, 2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Zhizhong Pan, Ph.D., Professor, Department of Pain Medicine, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Seminar Title: “Interaction of Pain and Emotional Responses”

Date: Tuesday, June 16, 2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Yuan-Xiang Tao, M.D., Ph.D., Professor, Vice Chair of Research, Department of Anesthesiology, Rutgers University
Seminar Title: "Discovery of Endogenous Long Non-Coding RNAs and Their Involvement in Neuropathic Pain”

Date: Tuesday, June 9,2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Zhou-Feng Chen, Ph.D., Professor, Director, Center for the Study of Itch Department of Anesthesiology, Psychiatry, Developmental Biology, Washington University School of Medicine in St. Louis
Seminar Title: “Why We Scratch: Molecular and Neural Basis of Itch”

Date: Monday, June 1, 2015
Time: 9:30 AM
Location: Kelsey Library
Journal Club, Burke Center for Pain and Sensory Recovery
Presenter: John Cave, Ph.D. (Cave lab)
Paper: "Epigenetic suppression of GAD65 expression mediates persistent pain." Nature Medicine 17 (2011) 1448-1455.

Date: Monday, April 27, 2015
Time: 9:30 AM
Location: Kelsey Library
Journal Club, Burke Center for Pain and Sensory Recovery
Presenter: Wilfredo Mellado, Ph.D. (Willis lab)
Paper: “Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain.” Gene Therapy (2013) 20, 742–750

Date: Tuesday, April 7, 2015
Time: 12:30 PM
Location: Rosedale Conference Room
Presenter: Clifford J. Woolf, MB, BCh, Ph.D., Professor, Director, F.M. Kirby Neurobiology Center & Program in Neurobiology, Boston Children's Hospital, Harvard Medical School
Seminar Title: "Pain and Neurodegeneration in a Dish"

March 4, 2016
Dr. Jian Zhong and Dr. John Cave are co-authors of a new Burke study titled "Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models" published in the March issue of Science Translational Medicine. The senior author of this study is Dr. Rajiv Ratan, Burke Professor in Neuroscience.

March 1, 2016
Dr. Jian Zhong published an invited review article titled “RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction" in Biological Chemistry - De Gruyter, an official journal of the German Society for Biochemistry and Molecular Biology -Gesellschaft für Biochemie und Molekularbiologie (GBM).

December 8, 2015
Dr. Dianna Willis published a paper in collaboration with Burke investigator Brett Langley titled “Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration” in PNAS (112:15220-5). The first author of this study is Dr. Camille Brochier, an Instructor in the Langley lab.

December 8, 2015
Drs. Dianna Willis and John Cave published a review article “Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST)” in Neurosci Lett. 2015 Dec 8. Dr. Meng Wang and technicians Elizabeth Brown and Lilah Fones L of Cave labs are co-authors of this article.

June 17, 2015
Dr. Jian Zhong is co-author of a research article “Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway” by Latremoliere et al., published in Neuron. 2015 Jun 17;86(6):1393-406.

September 29, 2015
Dr. Kevin O’Donovan and Dr. Jian Zhong are co-authors of a research article “Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation” by Huang S, O'Donovan KJ, Turner EE, Zhong J, Ginty DD, published in Elife. 2015 Sep 29;4.

April 18, 2016
Dr. Jian Zhong was invited to give a talk at the Wings for Life Conference, Salzburg, Austria.

December 4, 2015
Dr. Jian Zhong was invited to give a talk at the Vollum Institute, Oregon Health & Science University, Portland, OR.

December 2, 2015
Dr. Francesco Boato from the Zhong lab was invited to give a talk at the 16th International Symposium on Neural Regeneration, Asilomar, CA. Read more >

October 18, 2015
Dr. Dianna Willis was invited to give a talk entitled “Transcriptomic Approaches to Neural Regeneration” at the Society for Neuroscience Annual Meeting in Chicago, IL.

September 18, 2015
Dr. Jian Zhong was invited to give a talk at the Centre for Integrative Biology, University of Trento, Italy.

July 7, 2015
Dr. Jian Zhong was invited to give a talk at Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

June 30, 2015
Dr. Jian Zhong was invited to give a talk at the Francis Crick Symposium: Advances in Neuroscience, Suzhou, China.

May 12, 2015
Dr. Mariel Voutounou of Zhong lab was invited to give a talk at the Gotham Society for Mouse Development meeting. New York.

April 29, 2015
Dr. Jian Zhong was invited to give a talk at the Neurosurgery Grand Rounds, Mount Sinai School of Medicine, New York.

October 1, 2014
The study "B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS" (J Exp Med 211:801) conducted in Dr. Zhong’s laboratory was selected as a key scientific article contributing to excellence in biomedical research by Global Medical Discovery. Kevin O’Donovan, Ph.D., and Kaijie Ma, B.M., are the co-first authors of this study.

September 13, 2014
Dr. Zhong was invited to give a presentation entitled "The effects of B-RAF kinase signaling on nervous system development, regeneration and function?" at the 2014 GBM Conference "Perspectives of Molecular Neuroscience in Health and Disease" in Bochum, Germany.