Research Papers since 2000
Kiss, G., Konrad, C., Doczi, J., Starkov, A. A., Kawamata, H., Manfredi, G., Zhang, S. F., Gibson, G. E., Beal, M. F., Adam-Vizi, V., Chinopoulos, C . 2013. The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level Phosphorylation. FASEB J 27:2392-2406.
Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi, Q. 2012. Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer’s disease-like calcium dysregulation. Neurobiology of Aging. 33: Pages 1121.e13–1121.e24. PMCID: PMC3321099. NIHMSID: NIHMS345041
Shi Q, Gibson GE. 2011. Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a. J. Neurochem. 118: 440-448. PMCID 3135703
Shi Q, Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng H, Gibson GE. 2011. Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. J. Biological Chemistry. 286: 17640-17648.
Nilsen LH, Shi Q, Gibson GE, Sonnewald U. (2011) Brain [U-13C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity. J. Neuroscience Research. 89(12):1997-2007.
Bubber P, Haroutunian V, Gibson GE, Blass JP. 2011. Abnormalities in the tricarboxylic acid (TCA) cycle in brain of schizophrenia patients. European Neuropsychopharmacology. 21:254-260. PMCID 3033969
Huang HM, Chen HL, Gibson GE (2010) Thiamine and Oxidants Interact to Modify Cellular Calcium Stores. Neurochem Res. 35:2107–2116. PMCID 3085841
Area-Gomez E, de Groof JD, Boldogh I, Bird TD, Gibson GE, Koehler CM, Duff KE, Naini A, Bonilla E, Yaffe MP, Pon LA, Schon EA. (2009) Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria. Am J Pathol. 175:1810-1816. PMCID 2774047
Yang L, Shi Q, Ho DJ, Starkov AA, Wille EJ, Xu H, Chen HL, Zhang S, Cliona M, Stack CM, Calingason NY, Gibson GE, Beal MF. (2009) Mice deficient in dihydrolipoyl succinyltransferase show increased vulnerability to mitochondrial toxins. Neurobiology of Disease. 36:320-330.
Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson GE, Beal MF. 2009. Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free Radical Biology and Medicine. 47:1019-1027. PMCID 2761144
Shi Q, Risa Ø, Sonnewald U, Gibson GE. 2009. Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J Neurochem. 54:111-8. PMCID 2750872
Karuppagounder SS, Pinto JT, Xu H, Chen LH, Beal MF, Gibson GE. 2009. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s Disease. Neurochemistry International. 54:111-118. PMCID 2892907
Karuppagounder SS, X H, Shi Q, Chen LH, Pedrini S, Pechman DP, Baker, HA, Beal MF, Gandy SE, Gibson GE. 2009. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer’s mouse model. Neurobiology of Aging. 30:1587-1600. PMCID 2782730
Karuppagounder SS, Xu H, Pechman D, Chen LH, Degiorgio LA and Gibson G E. (2008) Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochemical Research. 33, 1365-1372. PMCID:2870991
Calingasan NY, Ho DJ, Wille EJ, Campagna MV, RuanJ, Dumont M, Yang L, Shi Q, Gibson GE, Beal MF. (2008) Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Neuroscience. 153:986-996. PMCID 18423880
Shi Q, Xu H, Kleinman WA, Gibson GE. 2008. Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer’s disease. Biochim Biophys ActA Molecular Basis of Disease. 1782:229-238. PMCID: PMC3106300
Shi Q, Karuppagounder SS, Xu H, Pechman D, Chen H-L, Gibson GE. 2007. Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may underlie regional selective vulnerability. Neurochemistry International. 50:921-931. PMCID 2753422
Karuppagounder SS, Shi Q, Xu H, Gibson GE. 2007. Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiology of Disease. 26:353-362. PMCID 2753424.
Zhang L, Cooper AJL, Krasnikov BF, Xu H, Bubber P, Pinto JT, Gibson GE, Hanigan MH. 2006. Cisplatin-Induced Toxicity Is Associated with Platinum Deposition in Mouse Kidney Mitochondria in Vivo and with Selective Inactivation of the α-Ketoglutarate Dehydrogenase Complex in LLC-PK1 Cells. Biochemistry. 45:8959-8971.
Ke Z, Bowen WM, Gibson GE. 2006 Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochemistry International. 49:548-556.
Santos SS, Gibson GE, Cooper AJL, Denton TT, Thompson CM, Bunik VI, Alves PM and Sonnewald U. 2006. Inhibitors of a-Ketoglutarate Dehydrogenase Complex Alter [1-13C]Glucose and [U-13C]Glutamate Metabolism in Cerebellar Granule Neurons. Journal of Neuroscience Research. 83:450-458.
Murphy EJ, Huang H-M, Cowburn RF, Lannfelt L, Gibson GE. 2006. Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation. Brain Research Bulletin. 69:79-85.
Kim SY, Marekov L, Bubber P, Browne SE, Stavrovskaya I, Lee J, Steinert PM, Blass JP, Beal MF, Gibson GE and Cooper AJL. 2005. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochemical Research. 30:1245-1255.
Waagepetersen HS, Hansen GH, Fenger K, Lindsay JG, Gibson G, Schousboe A. 2006. Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α-ketoglutarate dehydrogenase. Glia. 52:225-231.
Bunik VI, Denton TT, Xu H, Thompson CM, Cooper AJL, Gibson GE 2005. Phosphonate analogues of α-ketoglutarate inhibit the activity of the α-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 44:10552-10561.
Huang HM, Chen HL, Xu H and Gibson GE. 2005. Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer’s disease. Free Radical Biol. Med. 39:979-989.
Ke ZJ, Calingasan NY, Karuppagounder SS, DeGiorgio LA, Volpe BT, Gibson GE. 2005. CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. J. Neuroimmunology. 164:85-92.
Krasnikov BF, Kim SY, McConoughey SJ, Ryu H, Xu H, Stavrovskaya I, Iismaa S, Mearns, B, RatanRR, Blass JP, Gibson GE, Cooper AJL. (2005) Transglutaminase activity is present in highly purified non-synaptosomal mouse brain and liver mitochondria. Biochemistry. 44(21):7830-7843. PMCID 2597021.
Ke ZJ, Calingasan NY, DeGiorgio LA, Volpe BT, Gibson GE. 2005. CD40-CD40L Interactions promote Neuronal Death in a Model of Neurodegeneration Due to Mild Impairment of Oxidative Metabolism. Neurochemistry International. 47:204-215.
Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE. 2005. Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurology. 57:695-703.
Shi Q, Chen HL, Xu H, and Gibson GE. 2005. Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. Journal of Biological Chemistry. 280:10888-10896.
Jeitner TM, Xu H, Gibson GE. 2005. Inhibition of α-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. J. Neurochem. 92:302-310.
Huang HM, Fowler C, Xu H, Zhang H, Gibson GE. 2005. Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer’s disease. Neurobiology of Aging. 29:651-658.
HuangHM, Zhang H, OuHC, Chen HL and Gibson GE. 2004. α-Keto-ß-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca2+ stores. Free Radical Biology and Medicine. 37:1779-1789.
Bubber P, Ke ZJ, and Gibson GE. 2004. Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochemistry International. 45:1021-1028.
Bubber P, Tang J, Haroutunian V, Xu H, Davis KL, Blass JP, Gibson GE. 2004. Mitochondrial enzymes in schizophrenia. Journal of Molecular Neuroscience. 24:315-321.
Klivenyi P, Starkov AA, Calingasan NY, Gardian G, Browne SE, Yang L, Bubber P, Gibson G E, Patel MS and Beal MF. 2004. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. J Neurochem. 88:1352-60.
Huang HM, Fowler C, Zhang H, Gibson GE. 2004. Mitochondrial heterogeneity within and between different cell types. Neurochemical Research. 29:651-658.
Huang HM, Ou HC, Xu H, Chen HL, Fowler C, Gibson GE. 2003. Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death. J. Neuroscience Research. 74:309-317.
Ke ZJ, DeGiorgio LA, Volpe BT, Gibson GE. 2003. Reversal of thiamine deficiency induced neurodegeneration. J Neuropathology and Experimental Neurology. 62:195-207.
Gibson GE, Kingsbury AE, Xu H, Lindsay JG, Daniel S, Foster OJF,LeesAJ, Blass JP. 2003. Deficits In tricarboxylic acid cycle enzyme in brains from patients with Parkinson’s Disease. Neurochemistry International. 43:129-135.
Huang HM, Zhang H, Xu H and Gibson GE 2003. Inhibition of the a-Ketoglutarate Dehydrogenase Complex Alters Mitochondrial Function and Cellular Calcium Regulation. Biochimica et Biophysica Acta Molecular Basis of Disease. 1637:119-126.
Gibson GE, Zhang H, Xu H, Park LCH, Jeitner TM. 2002. Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme. Biochim Biophys Acta. 1586:177-189.
Andreassen OA, Ferrante RJ, Huang H-M, Dedeoglu A , Park LP, Ferrante KL, Kwon JK, Borchelt DR, Ross CA, Gibson GE and Beal MF. 2001. Dichloroacetate stimulates pyruvate dehydrogenase and exerts therapeutic effects in transgenic mouse models of HD. Annals of Neurology. 50:112-117.
Zhang H, Huang HM, Carson R, Mahmood J, Thomas H, Gibson GE. 2001 Assessment of Membrane Potentials of Mitochondrial Populations In Living Cells. Analytical Biochemistry. 298:170-180.
Park LCH, Albers DS, Xu H, Lindsay JG, Beal MF, Gibson GE. 2001. Mitochondrial Impairment in the Cerebellum of the Patients with Progressive Supranuc-lear Palsy. Journal of Neuroscience Research. 66:1028-1034.
Park LCH, Zhang H and Gibson GE 2001. Co-culture with astrocytes or microglia protects metabolically impaired neurons. Mechanisms of Aging and Development. 123:21-27.
Simon DK, Lin MT, Ahn CH, Liu G-J, Gibson GE, Beal MF, Johns DR. 2001. Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics.73:113-116.
Chun HS, Gibson GE, DeGiorgio LA, Kidd V, Son JH. 2000. Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism. J. Neurochemistry. 76:1-13.
Calingasan NY and Gibson GE 2000. Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood brain barrier breakdown induced by impaired oxidative metabolism. Brain Research. 885:62-69
Gibson GE, Zhang H, Sheu K-FR and Park LCH. 2000. Differential alterations in antioxidant capacity in cells from Alzheimer patients. Biochimica Biophysica Acta. 1502:319-329.
Murphy EJ, Zhang H, Sorbi S, Rapoport SI, Gibson GE. 2000. Phospholipid composition and levels are not altered in fibroblasts bearing presenilin-1 mutations. Brain Res Bull. 52:207-212.
Gibson GE, Haroutunian V, Zhang H, Park LCH, Shi Q, Lesser M, Mohs RC, Sheu RK and Blass, JP 2000. Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. Annals of Neurology. 48(3)297-303.
Albers DS, Augood SJ, Park LCH, Browne SE, Martin DM, Adamson J, Hutton M, Standaert DG, Vonsatte JPJ, Gibson GE and Beal MF. 2000. Frontal lobe dysfunction in PSP: Evidence for oxidative stress and mitochondrial impairment. J. Neurochem. 74: 878-881.
Park LCH, Calingasa NY, Sheu K-FR, Gibson GE. 2000. Quantitative "aketoglutarate dehydrogenase activity in brain sections and cultured cells. Analytical Biochemistry. 277:86-93.
Calingasan NY, Huang PL, Chun HS, Gibson GE. 2000. Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. J. Neuropathology and Experimental Neurology. 59:207-217.
Park LCH, Calingasan NY, Uchida K, Zhang H, and Gibson GE 2000. Metabolic impairment induces brain cell-type selective changes in oxidative stress and cell death in culture. J. Neurochem. 74:114-124.
Chapter & Reviews since 2000
Gibson GE, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J.. 2013. Abnormal Thiamine-Dependent Processes in Alzheimer’s Disease. Lessons from Diabetes. Molecular and Cellular Neuroscience. 55:17-25. NIHMS 431588.
Gibson GE, Starkov A, Shi Q, Beal MF. 2012. α-Ketoglutarate Dehydrogenase Complex in Neurodegeneration. Mitochondria and Cell Signaling in Health and Disease. Edited by Sten Orrenius, Enrique Cadenas, and Lester Packer. CRC Press.
Gibson GE, Shi Q 2010. A mitocentric view of Alzheimer’s disease suggests multi faceted treatments. Journal of Alzheimer’s Disease. 20 (Supp 2): S591-S607. NIHMS289121. PMCID: PMC3085842
Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF. 2010. Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age associated neurodegenerative diseases. Biochimica et Biophysica Acta Molecular Basis of Disease (Special Issue: Mitochondrial Dysfunction). 1802:122–134. PMCID 2790547
Gibson GE, Karuppagounder SS, Shi Q. 2008. Oxidant induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer’s disease. (IN: Mitochondria and Oxidative Stress in Neurodegenerative Disorders. Editors Gibson GE, Ratan RR, Beal MF) Ann. N.Y. Acad. Sci. 1147: 221–232. PMCID 2744687
Karuppagounder SS and Gibson GE. 2008. Thiamine deficiency: a model of metabolic encephalopathy and of selective neuronal vulnerability. Metabolic Encephalopathy. Editor David W. McCandless. Springer Press. pp 235-260.
Shi Q and Gibson GE. 2007. Oxidative stress and transcriptional regulation in Alzheimer’s disease. Alzheimer Disease & Associated Disorders - An International Journal. 21(4):276-291.
Gibson GE, Blass JP 2007. Thiamine-dependent processes and treatment strategies in neurodegenerations. Antioxidants and Redox Signaling. 9(10) 1-15.
BunikVI, SchlossJV, PintoJT, Gibson GE, CooperAJL. 2007. Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases. Neurochemical Research. 32(4-5):871-892.
Joseph JA and Gibson GE. 2007. Chapter 4.2. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia. Handbook of Neurochemistry and Molecular Biology. 3rd Edition Volume 5. Brain energetics from genes to metabolites to cells: Integration of molecular and cellular processes. Edited by Gary E. Gibson and Gerald Dienel. pp 297-320.
Blass JP and Gibson GE. 2006. Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans. Journal of Alzheimer’s Disease. 9:207–218.
Gibson GE, Huang HMH 2005. Commentary. Oxidative stress in Alzheimer’s disease. Neurobiology of Aging. 26:575-578.
Gibson GE, Blass JP, Beal MF, Bunik V 2005. The α-Ketoglutarate dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Molecular Neurobiology. 31:1-31.
Gibson GE and Huang 2004. Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. J. Bioenergetics and Biomembranes. 36:335-341.
Ke ZJ and Gibson GE. 2004. Selective Response of Various Brain Cell Types During Neurodegeneration Induced by Mild Impairment of Oxidative Metabolism. Neurochemical Intl. 45:361-369.
Gibson GE and Huang HM. 2002. Oxidative processes in the brain and non-neuronal tissues biomarkers of Alzheimer’s disease. Frontiers in Bioscience. 7:d1007-1015.
Blass JP, Gibson GE and Hoyer S. 2002. The role of the metabolic lesion in Alzheimer’s Disease. J. Alzheimer’s Disease. 4:225-232.
Gibson GE. 2002. Interactions of oxidative stress with cellular calcium dynamics -and Glucose Metabolism In Alzheimer’s Disease. Free Radical Biology and Medicine. 32:1061-1070.
Gibson GE and Zhang H. 2002. Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration. Neurochemistry International. 40:493-504.
Gibson GE and Zhang H. 2001. Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer’s disease. The Journal of Alzheimer’s Disease. 3:329-338.
Gibson GE and Zhang H. 2000. Effects of Ginkgo biloba (EGb761) on metabolism of reactive oxygen species in fibroblasts from Alzheimer’s Disease patients and controls. In Advances in Ginkgo Biloba Extract Research Vol 8. ginkgo biloba Extract (EGB 761) as a neuroprotective agent from basic studies to clinical trials. edited by Y Christen. Salal editeur. Marseille IPSEN Foundation. pp 108-121.