Clinical Research

Pioneering Rehabilitation

Clinical Research

Clinical research is conducted to evaluate the effectiveness and safety of medications medical devices or procedures by studying their effects on human beings. Clinical research trials can be conducted by government agencies such as the National Institutes of Health, researchers affiliated with a hospital or university, independent researchers, or private industry such as pharmaceutical companies. Both the Burke Rehabilitation Hospital and Burke Medical Research Institute conduct clinical trials.

Volunteers, also known as study subject are recruited for clinical trials. Their eligibility to participate in this type of research is based on pre-determined criteria. Subjects are usually divided into two or more groups, including a control group that does not receive the experimental treatment, receives a placebo instead, or receives an already approved treatment for comparison purposes. Government agencies such as the Food and Drug Administration (FDA) either approve or deny approval of new treatments based on the results of clinical trials.

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Search Results

Your search for 'Stroke' matches these Clinical Studies:

  • Stroke

    Sponsoring Agency: Nexstim, Inc. | Jun 26, 2014 (ongoing)

    Transcranial Magnetic Stimulation and Task-Oriented Therapy

    The purpose of this study is to determine the effects of transcranial magnetic stimulation (TMS) and one-on-one task-oriented occupational therapy on functional motor recovery in individuals who experience hemiparesis as a result of a stroke.  The program consists of treatment 3 times per week over the course of 6 weeks, or 18 sessions.  

    • >18 years of age
    • An ischemic or hemorrhagic stroke suffered 3-12 months prior to the study
    • No other known brain abnormalities by history
    • A one-sided stroke resulting in upper extremity paresis
    • Some degree of motor dysfunction in the upper extremity 

    Zoe Tsagaris, M.S., OTR/L — Study Coordinator and Clinical Research Therapist
    Phone: (914) 597-2153
    Fax: (914) 368-3117
    kzt3001@med.cornell.edu

                     

  • Stroke

    May 12, 2014 (ongoing)

    Effect of Transcranial Stimulation Techniques on Seated Balance for Patients with Lateropulsion Following Ischemic Stroke.

    To determine if transcranial direct current stimulation or repetitive transcranial magnetic stimulation will create a short-term improvement in seated balance for patients with lateropulsion following ischemic stroke.

    Patients with ischemic stroke who are undergoing active, in-patient rehabilitation and exhibit signs of lateropulsion (also known as "pusher syndrome") following stroke.  

    Michael Reding, M.D.
    (914) 597-2470 
    mreding@burke.org

  • Stroke

    Sponsoring Agency: Dana Foundation | Apr 1, 2012 (ongoing)

    Epigenetic Predictors of Stroke Recovery

    We hope to better understand gene expression patterns via examination of epigenetic modifications in blood born cells.  Identifying genotype-phenotype correlations could lead to discovery of biomarkers that predict recovery after stroke.

    Rajiv Ratan, M.D., Ph.D. and Andrew Goldfine, M.D.

    Patients with a first-time stroke

    Juliana Kennedy, B.S.
    jkennedy@burke.org 

  • Stroke

    Sponsoring Agency: Burke Foundation | Mar 1, 2012 (ongoing)

    Dietary Intervention in Stroke Recovery in the Acute Rehabilitation Setting with the Modified Atkins Diet.

    We aim to examine whether the use of a dietary intervention, the Modified Atkins Diet, can  improve motor recovery in stroke survivors.

    Carolin I Dohle, M.D.; Rajiv Ratan, M.D., Ph.D.

    Patients with a first-time, unilateral, hemispheric stroke who are admitted to the inpatient stroke rehabilitation unit.

    Carolin Dohle, M.D.
    (914) 597-2309
    cdohle@burke.org

  • Stroke

    Sponsoring Agency: NIH | Dec 1, 2011 - Nov 30, 2016

    Robotic Motor Training Combined with Non-Invasive Brain Stimulation to Enhance Motor Control in Hemiplegia

    The goal of this work is to enhance and better understand motor recovery after stroke, and to develop new treatments that maximize this recovery.                            

    Chronic stroke

    Avrielle Rykman M.A., OTR/L
    (914) 597-2220
    Mar Cortes, M.D.
    (914) 368-3181  
    robotics@burke.org

  • Stroke

    Sponsoring Agency: NIH | Nov 10, 2011 (ongoing)

    Evaluation of the variance of transcranial magnetic stimulation (TMS) measures in subacute and chronic stroke and the elderly

    The purpose of this study is to better understand the variance in measures of corticospinal tract integrity and excitability in different populations.  

    Dylan Edwards, Ph.D., P.T.
    Heidi Schambra, M.D.

    Chronic stroke

    Heidi Schambra, M.D.
    (914) 368-3126
    hschambra@burke.org

  • Stroke

    Nov 8, 2011 - Dec 30, 2015

    Transcranial Techniques for Patients with Lateropulsion Following Stroke.

    A study of possible changes in brain activity, as measured by transcranial magnetic stimulation, following the use of transcranial direct current stimulation in patients with lateropulsion ("pusher syndrome") following stroke.

    Suzanne R. Babyar, P.T., Ph.D.
    Dylan Edwards, Ph.D., P.T.
    Michael Reding, M.D.

    Patients with stroke who are undergoing active, in-patient rehabilitation and exhibit signs of lateropulsion (also known as "pusher syndrome") following stroke.

    Suzanne R. Babyar, P.T., Ph.D.
    (914) 597-2839
    sbabyar@burke.org

  • Stroke

    Dec 1, 2009 (ongoing)

    Use of a wakefulness-promoting agent (armondafinil) combined with neuro-rehabilitation to improve neurological recovery and to reduce the incidence of disability in patients who suffered a stroke

    This study is investigating whether intensive neurorehabilitative training and treatment with armodafinil can improve upper and lower motor coordination and strength. This study is investigating whether intensive neurorehabilitative training and treatment with armodafinil can improve upper and lower motor coordination and strength.

    Pasquale Fonzetti, M.D., Ph.D.

    This study includes stroke patients with a recent, first-time ischemic or hemorrhagic stroke (within the last 3 weeks) who have moderate to severe motor impairment (combined Fugl-Meyer score > 25).  Other criteria for participation may apply.

    Diana Zondorak, M.A.
    (914) 597-2827
    dzondorak@burke.org

  • Stroke

    Sponsoring Agency: NIH | Feb 1, 2006 (ongoing)

    IRIS: Insulin resistance intervention after stroke or TIA

    This study is attempting to prevent recurrent stroke, heart attack, and diabetes by controlling insulin resistance after stroke.

    Pasquale Fonzetti, M.D., Ph.D.

    This study includes non-diabetic stroke patients with a recent ischemic stroke (within the last 6 months) who are determined to be insulin resistant by a screening blood test.  Other criteria for participation may apply.

    Diana Zondorak, M.A.
    (914) 597-2827
    dzondorak@burke.org

Archived Projects

  • Stroke

    Sponsoring Agency: Johnson & Johnson | Jan 13, 2011 - Apr 1, 2012

    Application of novel robotic technology to develop sensitive biomarkers

    Longitudinal Study examining neurological & motor recovery Day 7,14,21,30 & 90 post onset of acute CVA 

    Bruce T.Volpe - NY/Cornell

    Inpatients

    Avrielle Rykman, MA,OTR/L
    (914) 597-2220 

  • Stroke

    Sponsoring Agency: Burke Foundation | Mar 1, 2011 - Sep 30, 2012

    Evaluation of the effect of transcranial direct current stimulation and robotic training on clinical, kinematic and neurophysiologic outcomes in subacute stroke patients

    The purpose of this study is to improve upper-limb motor recovery by pairing neuromodulation and robotic training and to characterize the physiology of the recovery. 

    Carolin Dohle, M.D.
    Dylan Edwards, Ph.D., P.T.

    Subacute stroke patients

    Carolin Dohle, M.D.
    (914) 597-2886
    cdohle@burke.org

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