The difference in rehab is Burke
Hope through Rehabilitation & Research

Clinical research is conducted to evaluate the effectiveness and safety of medications medical devices or procedures by studying their effects on human beings. Clinical research trials can be conducted by government agencies such as the National Institutes of Health, researchers affiliated with a hospital or university, independent researchers, or private industry such as pharmaceutical companies. Both the Burke Rehabilitation Hospital and Burke Medical Research Institute conduct clinical trials.
Volunteers, also known as study subject are recruited for clinical trials. Their eligibility to participate in this type of research is based on pre-determined criteria. Subjects are usually divided into two or more groups, including a control group that does not receive the experimental treatment, receives a placebo instead, or receives an already approved treatment for comparison purposes. Government agencies such as the Food and Drug Administration (FDA) either approve or deny approval of new treatments based on the results of clinical trials.
Viewing all current Clinical Studies:
Pilot trial of non-invasive brain stimulation for tinnitus
One percent of the population has treatment-resistant tinnitus, which can cause significant problems in daily living, such psychological distress, insomnia, etc. Repetitive transcranial magnetic stimulation of the brain hearing area may reset sensory perception and reduce tinnitus.
Douglas Labar, MD, PhD; Dylan Edwards, PhD; Mar Cortes, MD
Adults with treatment-resistant tinnitus for more than 6 month.
Dr. Labar, 212-746-2359
Placebo-Controlled Randomized Withdrawal Evaluation of the Efficacy and Safety of Baclofen ER Capsules (GRS) in Subjects with Spasticity Due to Multiple Sclerosis - CLR_09_21
Argyrios Stampas, M.D.
Multiple sclerosis patients, 18 years or older, on a stable dose of oral Baclofen, 30 to 60 mg, and have spasticisty in legs.
Rosanna Cirio at (914) 597-2476
Epigenetic Predictors of Stroke Recovery
We hope to better understand gene expression patterns via examination of epigenetic modifications in blood born cells. Identifying genotype-phenotype correlations could lead to discovery of biomarkers that predict recovery after stroke.
Rajiv Ratan, MD, PhD and Jessica Elder, MPH, PhD
Patients with a first time stroke
Jessica Elder, PhD: 914-368-3158 or jelder@burke.org
Dietary Intervention in Stroke Recovery in the Acute Rehabilitation Setting with the Modified Atkins Diet.
We here aim to examine whether the use of a dietary intervention, the Modified Atkins Diet, can improve motor recovery in stroke survivors.
Carolin I Dohle, MD; Raj Ratan MD PhD
Patients with a first time, unilateral, hemispheric stroke that are admitted to the inpatient stroke rehabilitation unit.
Carolin Dohle, MD; 914-597-2309; cdohle@burke.org
Robotic Motor Training Combined with Non-Invasive Brain Stimulation to enhance Motor Control in Hemiplegia
The goal of this work is to enhance and better understand motor recovery after stroke, and to develop new treatments that maximize this recovery.
Dylan J Edwards, PT, PhD
Chronic stroke
Avrielle Rykman MA, OTR/L - (914) 597-2220
Mar Cortes, MD (914) 368-3181
clinicaltrials@burke.org
PRISM, "The Pseudobulbar affect registry series"
The objective of the registry is to determine the prevalence of pseudobulbar
affect (PBA) in patients with certain underlying neurologic conditions: Alzheimer’s Disease
(AD), Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson’s Disease (PD),
Stroke (STR), and Traumatic Brain Injury (TBI).
Pasquale Fonzetti, M.D., Ph.D
Individuals 18 years or older with Alzheimer’s Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson’s Disease (PD), Stroke (STR), and Traumatic Brain Injury (TBI).
Rosanna Cirio, M.A.
914-597-2476
rcirio@burke.org
Effect of Neuromuscular Electrical Stimulation to the Neck Muscles in Individuals with Stroke and Lateropulsion.
A study of the possible effect of subthreshold neuromuscular stimulation of the neck muscles on lateropulsion ("pusher syndrome" following stroke.
Babyar SR
Reding M
Matuszewski J
Lasko L.
Patients with stroke who are undergoing active, in-patient rehabilitation and exhibit signs of lateropulsion (also known as "pusher syndrome") following stroke.
Suzanne R. Babyar, PT, PhD
914-597-2839
sbabyar@burke.org
The Interaction of Weight Shift on Scapulothoracic Movement of Individuals with Hemiparesis with and without Taping
A study about the interaction of scapular movements during reaching, weight shift, and kinesiotape application of individuals with chronic stroke and healthy controls.
Babyar SR
Holland T
O’Connor M
Lagatutta J
Gerkhardt L.
Healthy controls over 60 year and patients with stroke who have undergone an active rehabilitation program, can walk independently with or without a cane and who can reach their affected arm to 90 degrees and who can stand for approximately 1 hour. Participants must be free of allergies to medical or athletic tape
Suzanne R. Babyar, PT, PhD
914-597-2839
sbabyar@burke.org
Evaluation of the variance of transcranial magnetic stimulation (TMS) measures in subacute and chronic stroke and the elderly
The purpose of this study is to better understand the variance in measures of corticospinal tract integrity and excitability in different populations.
Dylan J Edwards, PT, PhD
Heidi Schambra, MD
Chronic stroke
Heidi Schambra, MD
hschambra@burke.org
Factors Predicting Outcome of Patients with Unilateral Total Knee Arthoplasty
A prospective, observational study of the factors that influence recovery during in-patient rehabilitation of individuals who have unilateral total knee arthroplasty.
Herbold, J
Bonistall K
Konjar T
Coggins E
Carr K
Ronda-Velez Y
Malcolmson L
Shah B
Babyar SR.
Patients with first, unilateral total knee replacement arthroplasty.
Janet Herbold PT, MPH
914-597-2357
jherbold@burke.org
Transcranial Techniques for Patients with Lateropulsion Following Stroke.
A study of possible changes in brain activity, as measured by transcranial magnetic stimulation, following the use of transcranial direct current stimulation in patients with lateropulsion ("pusher syndrome") following stroke.
Babyar, S.R.
Edwards, D.
Reding, M.
Patients with stroke who are undergoing active, in-patient rehabilitation and exhibit signs of lateropulsion (also known as "pusher syndrome") following stroke.
Suzanne R. Babyar, PT, Ph.D.
(914) 597-2839
sbabyar@burke.org
Upper-extremity robotic training study in chronic SCI
The purpose of this study is to investigate the mechanisms of the motor recovery in patients with chronic loss of function in the upper-limb after SCI, and to characterize the neurophysiological profile of patients and specific muscles that respond to robotic motor training by using Non-invasive brain stimulation, Transcranial Magnetic Stimulation (TMS).
Dylan J Edwards, PT, PhD
Spinal cord injury subjects, with cervical lesions, >1 year after the injury
Mar Cortes, MD
(914) 368-3181
clinicaltrials@burke.org
Use of a wakefulness-promoting agent (armondafinil) combined with neuro-rehabilitation to improve neurological recovery and to reduce the incidence of disability in patients who suffered a stroke
This study is investigating whether intensive neurorehabilitative training and treatment with armodafinil can improve upper and lower motor coordination and strength. This study is investigating whether intensive neurorehabilitative training and treatment with armodafinil can improve upper and lower motor coordination and strength.
| Pasquale Fonzetti, M.D., Ph.D. |
This study includes stroke patients with a recent, first-time ischemic or hemorrhagic stroke (within the last 3 weeks) who have moderate to severe motor impairment (combined Fugl-Meyer score > 25). Other criteria for participation may apply.
Diana Zondorak, M.A
914-597-2827
dzondorak@burke.org
Neurophysiological studies of neurological disorders of consciousness
Observational study of patients with severe brain injury from stroke or TBI who are not fully conscious to determine the underlying mechanisms of recovery of consciousness and if patients have residual levels of consciousness not detected on behavioral exam. Uses behavioral testing, EEG, MRI and PET brain imaging. All studies performed at NYP-Cornell Medical Center.
Andrew Goldfine, MD
Nicholas Schiff, MD
Patients in vegetative and minimally conscious state after traumatic brain injury or stroke.
Jennifer Hersh
(646) 962-8032
jeh2015@med.cornell.edu
IRIS: Insulin resistance intervention after stroke or TIA
This study is attempting to prevent recurrent stroke, heart attack, and diabetes by controlling insulin resistance after stroke.
Pasquale Fonzetti, MD, PhD
This study includes non-diabetic stroke patients with a recent ischemic stroke (within the last 6 months) who are determined to be insulin resistant by a screening blood test. Other criteria for participation may apply.
Diana Zondorak, M.A.
dzondorak@burke.org
914-597-2827
Modulation of Spinal Excitability with Repetitive Paired TMS (Transcranial Magnetic Stimulation) and Peripheral Nerve Stimulation
The purpose of this study is to investigate the changes in the excitability of spinalcord before and following a period of repetitive and synchronized dual peripheral nerve and brain stimulation.
Dylan J Edwards, PT, PhD
Spinal cord injury subjects, >1 year after the injury
Mar Cortes, MD
(914) 368-3181
clinicaltrials@burke.org
Quantification of Unilateral Neglect
This study will lead to developing a superior diagnostic tool for visuospatial neglect.
Dylan J Edwards, PT, PhD
Glen Prusky, PhD
In-patients at Burke with visuo-spatial neglect (stroke, TBI)
Dylan Edwards, PT, PhD
(914) 368-3080
Application of novel robotic technology to develop sensitive biomarkers
Longitudinal Study examining neurological & motor recovery Day 7,14,21,30 & 90 post onset of acute CVA
Bruce T.Volpe - NY/Cornell
Inpatients
Avrielle Rykman, MA,OTR/L
(914) 597-2220
Evaluation of the effect of transcranial direct current stimulation and robotic training on clinical, kinematic and neurophysiologic outcomes in subacute stroke patients
The purpose of this study is to improve upper-limb motor recovery by pairing neuromodulation and robotic training and to caracterize the physiology of the recovery.
Carolin Dohle, MD
Dylan Edwards, PT, PhD
Subacute stroke patients
Carolin Dohle, MD - 914-597-2886
cdohle@burke.org
Upper extremity motor cortex mapping in chronic thoracic SCI study
This study investigates the motor cortex map representation of hand muscles in chronic spinal cord injury subjects with paraplegia (thoracic lesions).
Dylan J Edwards, PT, PhD
Spinal cord injury population with toracic lesions, paraplegics, >6 months after the injury
Mar Cortes, MD; Robin Cash
(914) 368-3181
clinicaltrials@burke.org
Effectiveness of CPM Use in Inpatient Rehabilitation Hospital following Total Knee Replacement: A Prospective Randomized Control Trial
The purpose of this study is to determine the effectiveness of the continuous passive motion (CPM) device in conjunction with standard exercises for TKA patients in post-acute rehabilitation in an Inpatient Rehabilitation Facility (IRF) when compared to standard therapy alone.
Janet A. Herbold, PT, MPH
Suzanne Babyar, PT, PhD
Kristen Bonistall, MS, MSW
Banny Shah, PT
Lisa Malcomson, PT
Patients between the ages of 40 and 85 who underwent unilateral knee replacement due to osteoarthritis and who are admitted for continued in-patient rehabilitation at Burke Rehabilitation Hospital. The main inclusion criteria is an active flexion range of motion between 45 and 75 degrees.
Janet Herbold, PT, MPH
914-597-2357
jherbold@burke.org