As a leader in rehabilitation research striving to make scientific discoveries that will better the lives of those suffering from disability stemming from injury or illness, Burke Rehabilitation Hospital and Burke Medical Research Institute conduct ongoing basic, translational and clinical research. From time-to-time, Burke will recruit subjects its clinical trials. If you are interested in being part of a study, bookmark this page and check it occasionally for trials in need of subjects.
Below are Burke's medical research studies currently enrolling participants.
Clinical Research Study for Dementia and Alzheimer's Disease Patients
Burke Rehabilitation Hospital is currently conducting a clinical trial to evaluate whether enhancing brain glucose utilization minimizes cognitive decline in patients with Amnestic Mild Cognitive Impairment or mild Alzheimer's disease dementia. Thiamine (vitamin B1) is closely linked to memory and cognition. Many thiamine dependent processes are diminished in AD. The goal of this trial is to determine if increasing brain thiamine availability with the investigational new drug benfotiamine will minimize the decline in glucose utilization and slow the cognitive decline associated with AD.
Individuals who are at least 60 years old and with a diagnosis of Mild Cognitive Impairment or Alzheimer's disease may be eligible for participation. Study related evaluations include laboratory, comprehensive neurological examination, neuropsychological assessments, and Amyloid and Glucose PET imaging. Study participation will be over a 12 month period and will include follow-up visits to our clinic every 3 months. There are no costs associated with participation in this study.
Burke Rehabilitation Center is the designated location for this trial and is supported by the National Institute of aging (NIA) and the Alzheimer’s Disease Discovery Foundation (ADDF).
If you would like more information regarding this study, please contact: Rosanna Cirio, MA at 914-597-2476 or firstname.lastname@example.org
Clinical Research Study for Spinal Cord Injury
Burke Medical Research Institute is currently looking for subjects with spinal cord injury for a clinical research study. The goal of the study is the use of non-invasive brain stimulation and peripheral nerve stimulation to enhance lower extremity motor recovery.
If you are interested in learning more about the clinical research conducted at the ‘Noninvasive Brain Stimulation and Human Motor Control Laboratory’ and/or if you fit the inclusion criteria below, please contact Mar Cortes, M.D. at email@example.com or at (914) 368-3181.
‘Non-invasive stimulation for improving lower limb motor function after spinal cord injury’ study inclusion criteria:
- Spinal cord injury individuals over 18 years old
- Time since injury (more than 6 months)
- Presence of some degree of movement in the lower extremity (ankle muscles, ability to move the ankle)
- Incomplete lesions (AIS B, C, D)
- Medically stable
- Absence of other neurological/psychiatric disorder
- Absence of metal implants in the brain
You can learn more about this particular study in our patient handout.
Clinical Research Study for Patients with Spasticity Due to MS
Burke Rehabilitation Hospital is currently looking for patients with spasticity due to Multiple Sclerosis to participate in a clinical research study.
If you are over the age of 18, have difficulty moving your legs, and are taking Baclofen IR, you may be eligible for participation.
All patients will receive study medication and study-related care with a physician at no cost. Compensation for travel expenses is available.
To learn more contact Rosanna Cirio at (914) 597-2476.
Clinical Trial for Hand Therapy and Non-Invasive Brain Stimulation for Children with Hemiplegia
The Burke-Cornell Early Brain Injury Recovery Program is currently recruiting children with hemiplegia (weakness on one side of the body) for clinical trials involving high intensity hand therapy and non-invasive brain stimulation.
Children ages 1-18 are eligible. For more information, please e-mail the clinic.
Pharmacological Study for Improving Function Post Stroke
Burke Rehabilitation Hospital is currently seeking patients who have had an ischemic stroke and continue to have problems with sensorimotor abilities to evaluate the effects of dalfampridine on motor recovery. Dalfampridine (known under the trademark AMPYRA® of Acorda Therapeutics, Inc.) has been approved by the U.S. Food and Drug Administration (FDA) for patients with multiple sclerosis to help improve their ability to walk, but has not been studied in patients recovering from an ischemic stroke.
Pasquale Fonzetti, M.D., Ph.D., staff neurologist and associate director of Memory Evaluation and Treatment Service (METS) at Burke Rehabilitation Hospital and assistant professor of neurology at Weill Cornell Medical College, is the principal investigator for this study.
To pre-qualify for this study, you must:
- be between 18 and 85 years of age;
- have had an ischemic stroke six months ago or longer; and
- have a history of problems with sensorimotor abilities due to ischemic stroke.
All study-related visits, tests and study drugs will be provided at no cost. Compensation for time and travel may also be provided.
For more information about this study, please contact Diana Zondorak, Ph.D., clinical coordinator, at (914) 597-2827.