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Pioneering Rehabilitation

BMRI at Society for Neuroscience 2014 Meeting

Published November 11, 2014

Every fall since 1971, neuroscientists from around the world gather at the annual meeting of the Society for Neuroscience to share new research, learn from other experts, and build collaborations.  The meeting has become one of the largest and most prestigious for neuroscience professionals.

Among the more than 30,000 attendees at this year’s Society for Neuroscience meeting, held November 15-19 in Washington, D.C., will be over two-dozen researchers from the Burke Medical Research Institute.  Their presentations—which range from new findings on brain stimulation for cerebral palsy, to axonal regeneration in the central nervous system, to glucose metabolism in Alzheimer’s disease—reflect the wide range of cutting-edge research happening at BRMI.

Please click on the presentation titles below for more information.
 

Saturday, November 15

Paired motor cortex and cervical spinal cord stimulation augments corticospinal motor responses and promotes learning in the spinal cord of rats
A. M. Mishra, D. Gupta, J. B. Carmel

A novel, automated test of forelimb supination in the rat provides a sensitive measure of corticospinal tract function
A. Sindhurakar, B. Flynn, E. Meyers, D. Sloan, R. Rennekar, J. B. Carmel 

Transcranial direct current stimulation and upper extremity robotic therapy improves upper extremity function in an adult with cerebral palsy: a pilot study
K. M. Friel, P. Lee, D. Gupta, A. R. P. Smorenburg, H. -C. Kuo, D. J. Edwards

Sunday, November 16

Novel molecular mechanism in regulating tyrosine hydroxylase transcription
M. Wang, K. Banerjee, E. Cai, N. Fujiwara, H. Baker, J. W. Cave

Mild metabolic deficits in mitochondrial metabolism cause large changes in cell signaling - Relation to autophagy / mitophagy
K. Banerjee, D. Frank, J. Yang, S. Cho, T. T. Denton, G. E. Gibson

Are reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease beneficial or detrimental?
H. -L. Chen, T. Denton, G. E. Gibson

Inhibitors of HIF-proly-4-hydroxylases (HIF-PHD) mediate mitochondrial protection and prevent oxytosis in neuronal cells
S. Neitemeier, A. Dolga, S. Karuppagounder, R. Ratan, C. Culmsee

The variability of TMS measurements in healthy older adults and stroke patients
H. M. Schambra, I. E. Martinez-Hernandez, X. Lin, R. Ogden, D. J. Edwards, J. W. Krakauer

Monday, November 17 

CREB and AP1 co-regulate regeneration-associated gene expression and neurite growth on both permissive and inhibitory substrates
T. C. Ma, A. Barco, D. E., Willis, R. R. Ratan

Whole rat brain analysis of anterograde tracers from motor cortex and retrograde tracers from cervical spinal cord: Validation of an efficient, automated method with stereology
J. B. Carmel, F. Mechler, A. Mukherjee, T. Wen, A. Tolpygo, P. Mitra

Tuesday, November 18

Using transcription factors to promote the survival of transplanted cells for spinal cord injury repair
K. A. Scorpio, J. L. Brown, B. T. David, R. R. Ratan, C. E. Hill

Preventing neurodegeneration by inhibiting the correct HDACs: Molecular and pharmacological strategies
M. Bourassa, R. R. Ratan

Unilateral, but not bilateral motor cortex electrical stimulation promotes corticospinal function after injury
T. T. Bethea, Y. Haroonian, G. Drummond, A. Khalili, J. B. Carmel

Pharmacological inhibition of histone deacetylase-6 as a treatment for spinal cord injury
M. Metcalfe

Separate representations of the unimpaired and the impaired forelimbs in primary motor cortex following neonatal pyramidotomy in rats
T. Wen, D. Gupta, J. B. Carmel

Hydroxamic based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition
S. Sleiman, D. E. Olson, M. W. Bourassa, S. S. Karuppagounder, Y. -L. Zhang, J. Gale, F. F. Wagner, G. Coppola, J. Pinto, E. Holson, R. R. Ratan

Role of acetylation in the repair of DNA double-strand breaks in neurons
C. Brochier, R. Meyer, G. Dennis, B. Langley

Differential conservation of transcription factor codes specifying mouse and human olfactory bulb interneuron phenotypes
N. Fujiwara, J. W. Cave

HDAC6 inhibition promotes axon growth by selectively modifying the acetylome in the distal axon
A. L. Kalinski, P. Brito-Vargas, M. Riveccio, B. Langley, J. L. Twiss

Extracellular histones, a putative inhibitor of CNS axonal regeneration, are blocked by activated protein c (apc)
M. M. Siddiq, S. S. Hannila, Y. Zorina, V. Rabinovich, E. Nikulina, W. Mellado, R. Ivengar, M. T. Filbin

Wednesday, November 19

A précised investigation of the consequences of defects in glucose metabolism on optimal functioning of neurons in Alzheimer’s disease
A. Kumar, R. R. Ratan

A novel automated method for isolating and quantifying supination performance in a rat model of ischemic stroke
E. Meyers, A. Sindhurakar, S. Hays, A. Sloan, J. Carmel, M. Kilgard, R. Rennaker

Dynamic cortical lateralization during olfactory discrimination learning
Y. Cohen, D. Putrino, D. A. Wilson 

In vivo metabolism of TMPyP4 generates acetycholinesterase inhibitor-like activity
E. Cai, M. Wang, N. Fujiwara, J. Cave

Comparing anatomy and physiology of the corticospinal tract across subjects: Microstimulation motor mapping and retrograde tracing of motor cortex neurons co-registered in 3-dimensional space
D. Gupta, J. B. Carmel