Gary E. Gibson, Ph.D., and Jessica F. Elder, Ph.D., M.P.H, from the Burke Medical Research Institute collaborated with doctors Barry D. Jordan, M.D., M.P.H.; Pasquale Fonzetti, M.D., Ph.D.; Joseph Hirsch, Ph.D., Psy.D.; and ADAC coordinator Rosanna Cirio, M.A., from Burke Rehabilitation Hospital to write a chapter that summarizes findings from the Institute's study on Alzheimer's disease. The chapter talks about the results that demonstrate that the processes in the brain that require vitamin B1 are deficient in brains of Alzheimer's patients. Further, in models of Alzheimer's disease (AD), vitamin B1 deficiency promotes AD-like changes. In addition, the hallmarks of AD in models including memory deficits can be treated with vitamin B1 derivatives. Diabetes predisposes to AD, and the nerve damage in diabetics can be treated with vitamin B1 derivatives. The goal of the chapter is to promote therapeutic trials of AD based on these principles.
The chapter, “Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes,” was recently published in the journal Molecular and Cellular Neuroscience.